Increased serum concentrations of pigment epithelium-derived factor in patients with end-stage renal disease.
نویسندگان
چکیده
To the Editor: Pigment epithelium-derived factor (PEDF), a glycoprotein that belongs to the superfamily of serine protease inhibitors, was first purified from the conditioned media of human retinal pigment epithelial cells; it possesses potent neuronal differentiating activity (1). Recently, PEDF has been shown to be a highly effective inhib-itor of angiogenesis. In cell culture and in animal models, PEDF inhibited endothelial cell (EC) growth and migration and suppressed ischemia-induced neovascularization (1). In addition, PEDF was reported to inhibit tumor necrosis factor-␣-induced or angiotensin II-induced EC activation via its antioxidative properties (2). These observations suggest that PEDF may play a protective role against atherosclerosis by suppressing proliferative inflammatory responses to injuries in ECs. Therefore, characterization of the generation and clearance of PEDF could elucidate the pathophysiological role of this multifunctional protein in vivo. In a recent study of a general population of Japanese residents [mean (SD) age 65.7 (9.3) years; 71 men and 125 women] who showed no clinical evidence of coronary or peripheral arterial occlusive diseases, we found that serum PEDF concentrations showed a distribution, within the reference interval, of 8 to 24 mg/L [mean (SD) 14.6 (3.2) mg/L], and that uric acid (P Ͻ0.001), waist circumference (P ϭ 0.009), insulin (P ϭ 0.019), and triglycerides (P ϭ 0.028) were significant independent determinants of serum PEDF concentrations (3). In a previous study, we also showed that age-and uric acid-adjusted PEDF concentrations were substantially higher in proportion to the accumulation of components of the metabolic syndrome. Furthermore , the expression of PEDF in por-cine liver has been associated with body muscularity and obesity (3). In addition, the concentration of PEDF is down-regulated during the differentiation process of preadipocytes to mature adipocytes (3). These observations suggest that serum PEDF concentrations may increase as a counter-system against coronary risk factors in the metabolic syndrome and that liver and/or adipocytes may be a main source of PEDF in the circulation. However, the clearance of PEDF is not yet characterized, and we do not yet know the relation of serum PEDF concentrations to renal function. Therefore, in this study, we used an ELISA system to investigate whether serum concentrations of PEDF increased in patients with end-stage renal disease (ESRD). The study protocol was approved by our institutional ethics committee, and informed consent was obtained from study participants. We tested 50 patients [mean (SD) age, 60.5 (10.7) years] with clinical manifestations of ESRD— 46 were diagnosed …
منابع مشابه
Soluble Adiponectin is a New Predictor for Cardiovascular Complications in Patients with End Stage Renal Disease
Mortality due to cardiovascular complications (CVC) in patients with end stage renal disease (ESRD) is 20 fold higher than in general population. Adiponectin (ADPN) hormone from adipose tissues accumulation in serum is attributed to reduced renal clearance. The aim of this study was to investigate the possible role of ADPN as a predictor of CVC in adult patients with ESRD on hemodialysis (HD), ...
متن کاملFactors Associated with Uremic Pruritus in Patients Undergoing Hemodialysis: A report from Arak Valiasr Hospital
Background: Pruritus is one of the most disabling problems in patients with chronic renal failure. It is a distressing symptom with a negative impact on quality of life and is also very frustrating for both patients and their physicians. The pathophysiological mechanisms of pruritus are mainly unknown. The aim of this study was to identify factors associated with pruritus in these patients. Met...
متن کاملNeural Stem Cell-based Intraocular Administration of Pigment Epithelium-derived Factor Promotes Retinal Ganglion Cell Survival and Axon Regeneration after Optic Nerve Crush Injury in Rat: An Experimental Study
Background: Pigment epithelium-derived factor (PEDF) is regarded as a multifunctional protein possessing neurotrophic and neuroprotective properties. PEDF has a very short half-life, and it would require multiple injections to maintain a therapeutically relevant level without a delivery system. However, multiple injections are prone to cause local damage or infection. To overcome this, we chose...
متن کاملPrevalence of cutaneous manifestations in end stage renal disease patients under hemodialysis in Imam Khomeini Hospital, Tehran in 2003
Background and aim: New modalities in the treatment of end-stage renal disease (ESRD) patients have increased their life expectancy and quality of life. A wide range of cutaneous manifestations are seen in ESRD patients. This study was conducted to determine the prevalence of cutaneous manifestations in ESRD patients on maintenance hemodialysis in the dialysis department of Imam Khomeini ...
متن کاملThe role of hormones in renal disease and ischemia-reperfusion injury
The patients with renal diseases, especially end-stage renal disease (ESRD), are at high risk of developing cardiovascular disturbances. Some hormones such as brain natriuretic peptide appear to be important serum biomarkers in predicting cardiac death in ESRD patients. Renal diseases cause inflammation, anemia, uremic toxins, fluid overload, and electrolyte disturbance. Kidney transplantation ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- Clinical chemistry
دوره 52 10 شماره
صفحات -
تاریخ انتشار 2006